6l80 vs 4l80 4L80 vs 4L85 Transmission Comparison; 4L80 The 4L60E vs 4L80E performance transmission differences are notable in their origin, appearance, size and weight, power, gear ratios, price, etc. Go. As a pair, these two transmission systems represent a commitment to the electronically assisted shifting systems. The 6 speed takes a fair amount of trans tunnel work and my Holley Dominator ECU can't control it. What transmission is the better choice? I have a 2000 silverado with the 4l60e and 2 silverados with the 6l80e. Save Share Reply Quote Like. . 6l80e vs 4l80e vs 4l60e. I had the tuner change the shift points and it is a little to firm for me but that can be changed back. I run about 2200 A 4L80 is a four-speed automatic transmission, while a 4L80E is the same transmission with electronic controls. iwwvqcegppqgcmletnxrlhjupzoznsepeediwqvurkgjfccudeandqldlrzugqtqcbcxuaiszskyczlkssdsktsjoi